The Wegovy shot week
Wegovy (semaglutide) is injected once a week, and most people describe a weekly rhythm: appetite suppression strongest in the first two to three days after the shot, appetite and energy returning mid-week, and hunger strongest in the last day or two before the next injection. Because semaglutide has a long half-life, some people find the pattern flatter than they expected, particularly after several months at a stable dose.
Recompose is not affiliated with Novo Nordisk, who make Wegovy and Ozempic. This page describes commonly reported patterns to help you plan. It is not dosing information and does not replace the patient information leaflet or your prescriber.
The week, day by day
| Day | Stage | Commonly reported | A reasonable plan |
|---|---|---|---|
| Day 0: injection day | Injection | Usually much like any other day; some people feel flat by evening | Eat normally, log the shot, keep movement easy |
| Day 1 | Suppression begins | Appetite drops noticeably; nausea and reflux most likely here | Protein first, small and often, fluids, light movement only |
| Day 2 | Suppression peak | The lowest-appetite day for many people; tiredness common | Aim for protein alone; skip the workout without guilt |
| Day 3 | Suppression easing | Food starts to appeal again; energy lifting | Return to your full protein target; a short session if you feel it |
| Day 4 | Return | Often the best day of the week: appetite and energy both back | Your hardest resistance session; a full day of eating |
| Day 5 | Return | Steady; normal eating | Second solid session; keep protein high |
| Day 6: pre-shot | Pre-shot | Hunger strongest, cravings more likely as the dose wears off | Structure, volume and protein: planned meals rather than improvised ones |
What Wegovy users often notice
- A flatter curve than people expect, especially after months at the same dose.
- Reflux and early fullness reported more often than outright nausea by some people.
- A sharper week after each dose step-up, settling again after a fortnight or so.
Planning around it
The same approach applies as for any weekly GLP-1: no-cook protein ready for the suppression days, the hardest training session on a return day, and structured meals rather than improvised ones in the pre-shot window when hunger is strongest. Recompose does this scheduling for you through its cycle engine.
Common questions
Does Wegovy have a weekly cycle of side effects?
Many people describe one: strongest appetite suppression in the first two to three days after injecting, easing through the middle of the week. Because semaglutide is long-acting, the pattern is often less pronounced than with some other GLP-1s, and it tends to flatten after several months at a stable dose.
Is the Wegovy week the same as the Ozempic week?
Both contain semaglutide and are injected weekly, so the pattern people describe is broadly similar. They are licensed for different purposes and dosed differently, so how they are prescribed to you is a matter for your prescriber.
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